ABSTRACT
Objective: To compare CT features and clinical manifestations of adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) in the central airway. Methods: A total of 76 patients with central airway salivary gland tumor proved by surgery or biopsy (45 patients with ACC and 31 patients with MEC) were analyzed retrospectively. All patients underwent chest CT, among them 38 patients with ACC and 29 patients with MEC underwent contrast enhanced CT. CT features of the tumor, including growth location, maximum diameter, growth pattern, enhancement, obstructive pneumonia, atelectasis, lymphadenopathy and pleural effusion were evaluated. Results: Patients with MEC were younger than those with ACC (P0.05). Compared with MEC, ACC was more likely to occur in trachea, behaved as infiltrative growth, less enhancement and lower incidence of obstructive inflammation(all P0.05). Conclusion: The age of onset of central airway salivary gland tumor is younger. ACC is more likely to occur in the trachea, most of them show invasive growth, while enhancement CT shows mild to moderate enhancement. MEC is more likely to occur in lobar and segmental bronchi, most of them show expansive growth and significantly enhancement on CT. The incidence of obstructive inflammation is higher in MEC patients than in ACC patients.
ABSTRACT
Objective To investigate the expression of succinate dehydrogenase subunit A(SDHA)and subunit B (SDHB) in patients with renal cell carcinoma (RCC),and its relationship with the clinicopathologic characteristics. Methods The expression of SDHA and SDHB was detected in 179 cases of RCC by immunohisto-chemistry and the relationship between the SDHA ,SDHB expression and the clinicopathologic characteristics of RCC were analyzed. Results In 179 cases of RCC,18 cases(10.1%)were shown with negative or suspicious-negative expression of SDHA and SDHB,including 2 cases(1.1%)with suspicious-negative expression of SDHA and SDHB. 12 cases(66.7%)had tumor located in left kidney and 6 cases(33.3%)had tumor located in right kidney. The well-differentiation group contained 15 cases(83.3%),moderate-differentiation group contained 1 case (5.6%)and poor-differentiation group contained 2 cases(11.1%). Most of SDH negative and suspicious negative RCC had the following characteristics that the normal renal tubule could be seen within the tumor. The tumor was composed of polygonal cells arranged in nest ,and the polygonal cells were separated by a fine fibrovascular stroma. The nuclei were shown around with vesicular chromatin. The eosinophilic flocculet material ,vacuole and eosino-philic inclusion body could be seen in the cytoplasm of tumor cells. Conclusion The RCC cases with negative expression of SDHA and SDHB protein have unique histological features ,with significantly higher incidence in the left kidney than that in the right kidney.